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Source document· January 15, 2026

Morgan Stanley outlines path to $10T-plus client assets and sustained 20%+ ROTCE through market cycles

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Morgan Stanley outlines path to $10T-plus client assets and sustained 20%+ ROTCE through market cycles Earnings Call Insights: Morgan Stanley (MS) Q4 2025 MANAGEMENT VIEW * CEO Ted Pick opened with, "In 2025, the U.S…
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  • For remainder of 2026, assuming current forward curve, incremental loan growth and deposit mix projections, NII expected to continue to trend higher

    80% confidence
  • If there are lower asset prices due to drawdown, economic blip, or geopolitical event, there could be lower levels of performance

    80% confidence
  • If environment is welcoming, firm expects to execute at or above firmwide goals as in 2025; when backdrop is more challenged, aim to achieve higher lows

    80% confidence
  • Targets will be revisited later in the year; if clearly passed through, they will consider taking them higher

    80% confidence
  • Looking ahead to Q1 2026, NII expected to remain roughly flat quarter-over-quarter as higher average sweeps and lending balances offset the full impact of two rate cuts in Q4

    80% confidence
  • Morgan Stanley gained 100 basis points of wallet share in Institutional Securities

    80% confidence
  • Firm is focused on compounding earnings through the cycle rather than overreaching

    80% confidence
  • In 2025, the U.S. economy proved resilient with well-capitalized corporates and higher-end consumers driving the economy forward

    80% confidence
  • 2025 was an exceptional year for Morgan Stanley marked by deliberate execution of strategy

    80% confidence
  • Morgan Stanley is monetizing capital markets green shoots across investment banking and markets verticals, and scaling asset inflows and transaction activity across wealth businesses

    80% confidence
  • Wealth Management margin expansion driven by building out fee-based revenues and fee-based assets, plus efficiency through technology

    80% confidence
  • Equitization of markets around the world is underway; institutional trading wallet could continue to grow 5-10% per annum

    80% confidence
  • No philosophical frame shift on targets; firm now has confidence to discuss performance in more challenging environments with ability to still generate 17.5% ROTCE with earnings below $8

    80% confidence
  • Growth plans embed the increasing adoption of AI tools throughout the enterprise and inside client base

    80% confidence
  • This is not the time to overreach, emphasizing disciplined approach to capital deployment and M&A

    80% confidence
  • 2026 starts with the tailwinds of constructive fiscal policy and easier monetary policy

    80% confidence
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Q4 2026 Biotech Catalyst Cluster: Late-Stage Data and PDUFA Dates Converge
Early-to-mid November 2026 is a dense run of clinical readouts and Q3 earnings at AHA, AASLD, ACR and ASH. Mid-cap biotechs (Vir, Mineralys, Arrowhead, Oryzon, Novartis, J&J) are reporting data that feeds into regulatory decisions. The next ones are the ivonescimab BLA (Nov 14) and the lorundrostat PDUFA (Dec 22), followed by ECLIPSE 2/3 and Maritime-1 readouts in Q1 2027. The list also includes an unrelated delisting track (EGM Nov 19, application Jan 25, 2027), and the facts have no AI or fintech content.
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