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Source document· January 7, 2026

Merck Initiates Phase 3 KANDLELIT-007 Trial Evaluating Calderasib (MK-1084), an Investigational Oral KRAS G12C Inhibitor, in Combination With KEYTRUDA QLEX™ (pembrolizumab and berahyaluronidase alfa-pmph) in Certain Patients With Advanced NSCLC

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Merck Initiates Phase 3 KANDLELIT-007 Trial Evaluating Calderasib (MK-1084), an Investigational Oral KRAS G12C Inhibitor, in Combination With KEYTRUDA QLEX™ (pembrolizumab and berahyaluronidase alfa-pmph) in Certain Patients With Advanced NSCLC Third Phase 3 trial in Merck’s KANDLELIT clinical development program, whic…
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  • Merck operates the largest immuno-oncology clinical research program with over 1,600 trials across multiple cancers

    80% confidence

  • Combination of oral calderasib with subcutaneous KEYTRUDA QLEX will evaluate whether this chemotherapy-free combination requiring no intravenous access may help improve outcomes for patients with KRAS G12C-mutant NSCLC

    80% confidence

  • KRAS is the most frequently mutated oncogene in cancer, and the KRAS G12C mutation occurs in approximately 4% to 14% of all patients with lung cancer globally

    80% confidence
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Merck Initiates Phase 3 KANDLELIT-007 Trial Evaluating Calderasib (MK-1084), an Investigational Oral KRAS G12C Inhibitor, in Combination With KEYTRUDA QLEX™ (pembrolizumab and berahyaluronidase alfa-pmph) in Certain Patients With Advanced NSCLC — Source | Via News | fr.VIA.NEWS